The new EU Regulation on veterinary medicines, applicable from 28 January 2022, defines rules that also aim to reduce the use of antimicrobials in farmed and companion animals.

In the veterinary field, we are all called upon to use antimicrobials more prudently to tackle the development of resistance to these substances.

One of the major innovations of this rule concerns the use of antimicrobials, possible only upon veterinary prescription and to be justified by an accurate diagnosis of the condition of the animals1.

Regarding mastitis in dairy cows, beyond future regulatory provisions, prudent use of antibiotics can really help us reduce the costs associated with health treatments and minimize the risk of resistance development.

Improving efficective and consistent health and herd management is essential, but also detecting udder issue and their severity, the agent causing the problem and identify the right tool for defense.

In a few words (and in order): clinical examination, milk cultures and antibiogram testing.

Why should we conduct these three different steps?

To properly manage mastitis on dairy farms, identifying the specific issue and “measuring” its severity is the first thing to do. We recently discussed about it in an article2 illustrating the importance of observing the animal, udder and milk before milking to understand whether a secretory tissue disorder is in progress and to what extent.

This is for making decisions about how to act. Then we have to conduct milk cultures. The aim is to have information on the pathogens causing mastitis specifically for that farm, as well as on sensitivity to antibiotics, which will be assessed by conducting an antibiogram test.

This last test corresponds in fact to the antibiotic sensitivity test, and will be performed by an accredited laboratory according to the methods suggested by international reference standards. Unfortunately, the outcome of the antibiogram is not immediate, and could represent a limit when the intervention must necessarily be done promptly.

Actually, it is really useful: conducting an antibiogram helps us to collect information on how to act with respect to a future infection caused by the pathogen that we first identified with the bacteriological and then whose sensitivity to different antibiotics we assessed with the antibiogram.

While waiting for the result of the antibiogram, we can consider the application of OZOLEA-MAST.

For this reason, OZOLEA created Protocol M5 (Udder, lactation: severe mastitis or relapse, while waiting for sensitivity test results; warning: this protocol has no therapeutic effect), to be implemented under the observation of the veterinarian.

Why to use OZOLEA-MAST in this situation? OZOLEA-MAST is not intended to cure mastitis, but to support and protect the intra-mammary tissue. This means that it does not replace the antibiotic in cases of severe or recurrent mastitis, but can be used while waiting to know which antibiotic will be used.

Why? The support to the tissue functionality and the protection of OZOLEA-MAST allow the tissue to proceed with the natural regeneration process. The intra-mammary tissue is a natural defensive barrier: its integrity allows a better synergy with the effectiveness of the antibiotic.


1 Veterinary prescriptions and antimicrobials: new rules from 28 January 2022.

2 Early detection of mastitis: signs at cow, udder and milk level.